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办公室:上海大学宝山校区东区19号楼608室 电 话:021-66135167 E-mail:chenfuxue@staff.shu.edu.cn 个人简介: 男,博士,教授,博士生导师。上海大学生命科学学院党委书记。1999年7月博士毕业于西北农林科技大学动物遗传育种与繁殖专业。2001-2003年间在美国Georgia State University 从事细胞与分子生理学博士后研究工作。主持或以主要学术骨干参加科技部“973”、教育部留学归国人员基金、上海市自然科学基金、上海市教委重点创新项目、上海市农委攻关项目多项。讲授“动物学”、“神经生物学技术”、“生命科学导论”、“现代生物技术导论”等课程。荣获 “上海大学优秀青年教师”、“上海市优秀青年教师”称号。 电话:021-66135167 教育与工作经历: 1996/09-1999/07 西北农林科技大学,动物科学学院,获博士学位;1993/09-1996/07贵州大学,动物科学系,获硕士学位;1989/09-1993/07 西北农林科技大学,畜牧系,获学士学位。 2010/03-至今 上海大学 生命科学学院 教授;2003/03-2010/02 上海大学 生命科学学院 副研究员;2001/12-2003/03 美国佐治亚州立大学 博士后;1999/07-2003/02 上海大学 生命科学学院 讲师。 主要研究领域: 儿童自闭症基因编辑动物模型构建、自闭症分子生物学机制研究、恶性脑胶质瘤发生发展过程中信号通路的分子机制。 代表性研究成果:初步阐明了sat3等基因在恶性脑胶质瘤发生发展中的分子生物学机制;筛选出一些儿童自闭症易感基因,并构建了基因编辑动物模型。 近五年代表性论文: [1] Rescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats. Epilepsy & Behavior,(accept) [2] Increased Expression of Kv10. 2 in the Hippocampus Attenuates Valproic Acid-Induced Autism-Like Behaviors in Rats. Neurochemical research, 44(12), 2796-2808,201912 [3] Central changes in the Kv10.2 potassium channel in stress-induced hypertension rats, Neuroreport, 30(9):637-644,201906 [4] Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia,PLoS One,14(2),201902 [5] Quantitative Structure-activity Relationship of Acetylcholinesterase Inhibitors based on mRMR Combined with Support Vector Regression,Lett Org Chem,16(4):311-316,201902 [6] Berberine activates bitter taste responses of enteroendocrine STC-1 cells,Mol Cell Biochem,447(1-2):21-32,201810 [7] Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in rats,Auton Neurosci,213:71-80,201809 [8] Knockdown of Diaph1 expression inhibits migration and decreases the expression of MMP2 and MMP9 in human glioma cells,Biomed Pharmacother,96:596-602,201712 [9] CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1,Mol Cell Biochem,436(1-2):79-86,201712 [10] Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity,Oncotarget,8(34):57149-57162,201708 [11] Prediction of the aquatic toxicity of aromatic compounds to tetrahymena pyriformis through support vector regression,Oncotarget,8(30):49359-49369,201707 [12] A Cancer Gene Selection Algorithm Based on the K-S Test and CFS,Biomed Res Int,201705 [13] Prediction of an Interaction Between Bakuchiol and Acetylcholinesterase Using Adaboost,Curr Bioinform,11(1):79-86,2016 [14] Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts,Biochem Biophys Res Commun,463(4):934-941,201508 [15] Structural Characterization and Neurotrophic Activity Study of a Polysaccharide Isolated from Campanumoea javanica,J Carbohydr Chem, 34(4): 183-195,201505 [16] Expression of bitter taste receptor Tas2r105 in mouse kidney,Biochem Biophys Res Commun,458(4):733-738,201503 [17] 67kDa laminin receptor regulates the activation of MAPKs through DUSPs in glioma cell line U251,J BUON,20(1):253-260,201501 [18] Knockdown of PKC epsilon Expression Inhibits Growth, Induces Apoptosis and Decreases Invasiveness of Human Glioma Cells Partially Through Stat3,J Mol Neurosci, 55(1):21-31,201501 Normal07.8 磅02falsefalsefalseEN-USZH-CNX-NONE Normal07.8 磅02falsefalsefalseEN-USZH-CNX-NONE Normal07.8 磅02falsefalsefalseEN-USZH-CNX-NONE |